解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Interleukin-2 (IL-2) is a critical regulator of immune homeostasis through its non-redundant role in regulatory T (Treg) cell biology. There is major interest in therapeutic modulation of the IL-2 pathway to promote immune activation in the context of tumour immunotherapy or to enhance immune suppression in the contex...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/imm.12609
更新日期:2016-07-01 00:00:00
abstract::The concept of immunological tolerance--the state of specific unresponsiveness to allogeneic transplants and all manner of other antigens--began in 1945 with R.D. Owen's finding that cattle dizygotic twins are red blood cell chimeras. Peter Medawar's group in Birmingham likewise discovered, quite independently, that c...
journal_title:Immunology
pub_type: 历史文章,杂志文章,评审
doi:10.1111/imm.12567
更新日期:2016-03-01 00:00:00
abstract::Group 2 innate lymphoid cells (ILC2s) produce a significant amount of interleukin-5 (IL-5), which supports eosinophil responses in various tissues; they also produce IL-13, which induces mucus production and contributes to tissue repair or fibrosis. The ILC2s are activated by alarmins, such as IL-33 released from epit...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/imm.12537
更新日期:2016-01-01 00:00:00
abstract::Protein kinase C (PKC) form a key family of enzymes involved in signalling pathways that specifically phosphorylates substrates at serine/threonine residues. Phosphorylation by PKC is important in regulating a variety of cellular events such as cell proliferation and the regulation of gene expression. In the immune sy...
journal_title:Immunology
pub_type: 杂志文章,评审
doi:10.1111/imm.12510
更新日期:2015-12-01 00:00:00
abstract::Among their diverse roles as transcriptional regulators during development and cell fate specification, the RUNX transcription factors are best known for the parts they play in haematopoiesis. RUNX proteins are expressed throughout all haematopoietic lineages, being necessary for the emergence of the first haematopoie...
journal_title:Immunology
pub_type: 杂志文章,评审
doi:10.1111/imm.12535
更新日期:2015-12-01 00:00:00
abstract::The composition of the microbiome in health and disease has only recently become a major research focus. Although it is clear that an imbalance or dysbiosis in the microbiota is associated with disease, its interrelatedness to disease penetrance is largely unknown. Inflammatory bowel disease (IBD) is an excellent dise...
journal_title:Immunology
pub_type: 杂志文章,评审
doi:10.1111/imm.12511
更新日期:2015-11-01 00:00:00
abstract::Natural killer (NK) cells, which can exert early and powerful anti-tumour and anti-viral responses, are important components of the innate immune system. DNAX accessory molecule-1 (DNAM-1) is an activating receptor molecule expressed on the surface of NK cells. Recent findings suggest that DNAM-1 is a critical regulat...
journal_title:Immunology
pub_type: 杂志文章,评审
doi:10.1111/imm.12516
更新日期:2015-11-01 00:00:00
abstract::Leukotriene B4 (LTB4 ) is a lipid mediator that is rapidly generated in inflammatory sites, and its functional receptor, BLT1, is mostly expressed on immune cells. Contact dermatitis is a common inflammatory skin disease characterized by skin oedema and abundant inflammatory infiltrates, primarily including neutrophil...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/imm.12478
更新日期:2015-09-01 00:00:00
abstract::The role of Foxp3(+) regulatory T (Treg) cells in the course of the early hyper-inflammatory and subsequent hypo-inflammatory phases of sepsis is ambiguous. Whereas Nrp1 expression has been reported to discriminate natural Treg cells from induced Treg cells, the Treg cell stability depends on the methylation status of...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/imm.12490
更新日期:2015-09-01 00:00:00
abstract::Dengue virus (DENV) infection causes dengue fever, dengue haemorrhagic fever, or dengue shock syndrome. Mast cells have been speculated to play a role in DENV disease although their precise roles are unclear. In this study, we used mast cell-deficient Kit(W-sh/W-sh) mice to investigate the involvement of mast cells af...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/imm.12492
更新日期:2015-09-01 00:00:00
abstract::Invariant natural killer T (iNKT) cells are an innate population of T cells identified by the expression of an invariant T-cell receptor and reactivity to lipid-based antigens complexed with CD1d. They account for a small percentage of lymphocytes, but are extremely potent and play central roles in immunity to infecti...
journal_title:Immunology
pub_type: 杂志文章,评审
doi:10.1111/imm.12481
更新日期:2015-08-01 00:00:00
abstract::The gut immune system and its modification by diet have been implicated in the pathogenesis of type 1 diabetes (T1D). Therefore, we investigated gut immune status in non-diabetes-prone LEW.1AR1 and diabetes-prone LEW.1AR1-iddm rats and evaluated the effect of a low antigen, hydrolysed casein (HC)-based diet on gut imm...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/imm.12457
更新日期:2015-07-01 00:00:00
abstract::Mucosa-associated invariant T (MAIT) cells express the semi-invariant T-cell receptor TRAV1-2 and detect a range of bacteria and fungi through the MHC-like molecule MR1. However, knowledge of the function and phenotype of bacteria-reactive MR1-restricted TRAV1-2(+) MAIT cells from human blood is limited. We broadly ch...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/imm.12461
更新日期:2015-07-01 00:00:00
abstract::Gene transfer to create tumour epitope-specific cytolytic T cells for adoptive immunotherapy of cancer remains an area of active inquiry. When the Mart-127-35 -specific DMF5 T-cell receptor (TCR) is transferred into peripheral human CD4(+) T cells, the reprogrammed cells exhibit a T helper type 1 (Th1) phenotype with ...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/imm.12431
更新日期:2015-05-01 00:00:00
abstract::A decrease in the number of dendritic cells (DCs) is a major cause of post-sepsis immunosuppression and opportunistic infection and is closely associated with poor prognosis. Increasing the number of DCs to replenish their numbers post sepsis can improve the condition. This therapeutic approach could improve recovery ...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/imm.12423
更新日期:2015-05-01 00:00:00
abstract::Differences in the activity of monocytes/macrophages, important target cells of Mycobacterium tuberculosis, might influence tuberculosis progression. With the purpose of identifying candidate genes for tuberculosis susceptibility we infected monocytes from both healthy elderly individuals (a tuberculosis susceptibilit...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/imm.12371
更新日期:2015-02-01 00:00:00
abstract::Airway mucus hyperproduction is a common feature of chronic airway diseases such as severe asthma, chronic obstructive pulmonary disease and cystic fibrosis, which are closely associated with neutrophilic airway inflammation. S100A8, S100A9 and S100A12 are highly abundant proteins released by neutrophils and have been...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/imm.12352
更新日期:2015-01-01 00:00:00
abstract::Interleukin-19 (IL-19) plays an important role in asthma by stimulating T helper type 2 (Th2) cytokine production. Interestingly, IL-4, a key Th2 cytokine, in turn up-regulates IL-19 expression in bronchial epithelial cells, so forming a positive feedback loop. In atopic dermatitis (AD), another Th2 disease closely re...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/imm.12339
更新日期:2014-12-01 00:00:00
abstract::The development of improved vaccines and vaccination strategies against Mycobacterium tuberculosis has been hindered by a limited understanding of the immune correlates of anti-tuberculosis protective immunity. Simple measurement of interferon-γ frequency or production per se does not provide adequate prediction of im...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/imm.12348
更新日期:2014-12-01 00:00:00
abstract::Hepatitis C virus (HCV) infection is a global health problem characterized by a high rate of chronic infection, which may in part be due to a defect in myeloid dendritic cells (mDCs). This defect appears to be remedied by treatment with interferon-α (IFN-α) -based antiviral therapies; however, the molecular mechanisms...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/imm.12350
更新日期:2014-12-01 00:00:00
abstract::Nod-like receptors are a family of innate immune receptors that link cytosolic sensing of microbial and danger stimuli to the activation of immune responses. Two Nod-like receptor family members, Nod1 and Nod2, recognize bacterial peptidoglycan and activate immune responses via nuclear factor-κB (NF-κB) and mitogen-ac...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/imm.12307
更新日期:2014-10-01 00:00:00
abstract::Staphylococcus aureus is a major pathogen that can cause a broad spectrum of serious infections including skin infections, pneumonia and sepsis. Peritoneal mast cells have been implicated in the host response towards various bacterial insults and to provide mechanistic insight into the role of mast cells in intraperit...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/imm.12297
更新日期:2014-10-01 00:00:00
abstract::Immune synapse formation is critical for T lymphocyte activation, and mitochondria have a role in this process, by localizing close to the immune synapse, regulating intracellular calcium concentration, and providing locally required ATP. The interaction between antigen presenting cells (APCs) and T lymphocytes is a t...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/imm.12392
更新日期:2014-09-23 00:00:00
abstract::Although the co-stimulatory interaction between B and T cells is well defined, recent evidence suggests that B cells also have a regulatory role. Here, we show that B cells activated using anti-IgD conjugated to dextran (α-δ-dex) directly inhibit TCR-induced CD4 T cell activation, proliferation and cytokine production...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/imm.12389
更新日期:2014-09-20 00:00:00
abstract::Systemic lupus erythematosus (SLE) is an autoimmune disease in which abnormal immune responses are mediated by tissue-binding autoantibodies and immune complex deposition. Because most SLE patients are women of child-bearing age, oestrogen has been suggested to play an important role in SLE pathogenesis. One proposed ...
journal_title:Immunology
pub_type: 临床试验,杂志文章
doi:10.1111/imm.12263
更新日期:2014-08-01 00:00:00
abstract::Murine embryonic stem (ES) cell-derived haematopoietic progenitor cells (HPCs) engraft and populate lymphoid organs. In vivo, HPCs engraft across MHC barriers protecting donor-type allografts from rejection. However, the underlying phenomenon remains elusive. Here, we sought to determine the mechanism by which ES cell...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/imm.12268
更新日期:2014-07-01 00:00:00
abstract::The epigenetic regulation of transcription factor genes is critical for T-cell lineage specification. A specific methylation pattern within a conserved region of the lineage specifying transcription factor gene FOXP3, the Treg-specific demethylated region (TSDR), is restricted to regulatory T (Treg) cells and is requi...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/imm.12261
更新日期:2014-07-01 00:00:00
abstract::Antigen-induced allergic airway inflammation is mediated by T helper type 2 (Th2) cells and their cytokines, but the mechanism that initiates the Th2 immunity is not fully understood. Recent studies show that basophils play important roles in initiating Th2 immunity in some inflammatory models. Here we explored the ro...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/imm.12240
更新日期:2014-06-01 00:00:00
abstract::Dendritic cells (DCs) operate as the link between innate and adaptive immunity. Their expression of pattern recognition receptors (PRRs), such as Toll-like receptors (TLRs) and C-type lectin receptors (CLRs), enables antigen recognition and mediates appropriate immune responses. Distinct subsets of human DCs have been...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/imm.12252
更新日期:2014-06-01 00:00:00
abstract::Aspergillus fumigatus is often associated in asthmatic patients with the exacerbation of asthma symptoms. The pathomechanism of this phenomenon has not been fully understood. Here, we evaluated the immunological mechanisms and the role of the prostaglandin D2 / Chemoattractant Receptor-Homologous Molecule Expressed on...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/imm.12234
更新日期:2014-05-01 00:00:00
abstract::Vitamin A and its active metabolite retinoic acid are essential for the development and function of many tissues including the immune system. The induction of mucosal homing receptors on T and B cells by mucosal dendritic cells (DC) depends on the presence of vitamin A. Recent studies indicate that also the differenti...
journal_title:Immunology
pub_type: 杂志文章,评审
doi:10.1111/imm.12228
更新日期:2014-05-01 00:00:00
abstract::Regulatory T (Treg) cells act to suppress activation of the immune system and thereby maintain immunological homeostasis and tolerance to self-antigens. The frequency and suppressing activity of Treg cells in general are high in different malignancies. We wanted to identify the role and regulation of CD4(+) CD25(+) ...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/imm.12237
更新日期:2014-05-01 00:00:00
abstract::Newborn mammals are highly susceptible to respiratory infections. Although maternal antibodies (MatAb) offer them some protection, they may also interfere with their systemic immune response to vaccination. However, the impact of MatAb on the neonatal mucosal immune response remains incompletely described. This study ...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/imm.12222
更新日期:2014-04-01 00:00:00
abstract::Microglia cells, the resident innate immune cells in the brain, are highly active, extending and retracting highly motile processes through which they continuously survey their microenvironment for 'danger signals' and interact dynamically with surrounding cells. Upon sensing changes in their central nervous system mi...
journal_title:Immunology
pub_type: 杂志文章,评审
doi:10.1111/imm.12177
更新日期:2014-03-01 00:00:00
abstract::Loss of ζ-associated protein 70 (Zap70) results in severe immunodeficiency in humans and mice because of the critical role of Zap70 in T-cell receptor (TCR) signalling. Here we describe a novel mouse strain generated by N-ethyl-N-nitrosourea mutagenesis, with the reduced protein stability (rps) mutation in Zap70. The ...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/imm.12199
更新日期:2014-03-01 00:00:00
abstract::It is becoming increasingly clear that the T-cell-mediated immune response is important in many diseases. In this study, we used concanavalin A (Con A) -induced hepatitis to investigate the role of CD49a in the molecular and cellular mechanism of the T-cell-mediated immune response. We found that CD49a(-/-) mice had s...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/imm.12201
更新日期:2014-03-01 00:00:00
abstract::Oxidized low-density lipoprotein (OxLDL) plays a crucial role in the development of atherosclerosis. Carbamylated LDL has been suggested to promote atherogenesis in patients with chronic kidney disease. Here we observed that plasma IgG and IgM antibodies to carbamylated epitopes were associated with IgG and IgM antibo...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/imm.12204
更新日期:2014-03-01 00:00:00
abstract::CD4(+) FOXP3(+) regulatory T (Treg) cells constitute a heterogeneous and plastic T-cell lineage that plays a pivotal role in maintaining immune homeostasis and immune tolerance. However, the fate of human Treg cells after loss of FOXP3 expression and the epigenetic mechanisms contributing to such a phenotype switch re...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/imm.12198
更新日期:2014-03-01 00:00:00
abstract::The gut microbiota provides an important stimulus for the induction of regulatory T (Treg) cells in mice, whether this applies to newborn children is unknown. In Swedish children, Staphylococcus aureus has become a common early colonizer of the gut. Here, we sought to study the effects of bacterial stimulation on neon...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/imm.12209
更新日期:2014-03-01 00:00:00
abstract::Systemic lupus erythematosus (SLE) is an autoimmune disease that can attack many different body organs; the triggering event is unknown. SLE has been associated with more than 100 different autoantibody reactivities - anti-dsDNA is prominent. Nevertheless, autoantibodies to dsDNA occur in only two-thirds of SLE patien...
journal_title:Immunology
pub_type: 杂志文章
doi:10.1111/imm.12200
更新日期:2014-02-01 00:00:00